Andropause

Andropause Treatment and Men’s Hormonal Health in London

Restoring Strength, Energy, and Confidence Through Science

Andropause — sometimes called male menopause — is the gradual decline of testosterone and other key hormones that occurs with age.
It affects physical strength, motivation, mood, sexual health, and long-term vitality.

At Longevity Centre London, we combine advanced diagnostics, hormonal analysis, and regenerative therapies to identify and reverse the effects of andropause.
Our approach restores hormonal balance, improves energy and focus, and helps you feel younger and stronger for longer.

[Book Men’s Health Assessment → /health-assessments/]
[Learn About Testosterone Therapy → /testosterone-replacement-therapy/]

Understanding Andropause

Andropause is not a sudden hormonal change — it’s a slow, progressive process that begins as early as your thirties.
Testosterone, DHEA, and growth hormone levels start to fall, while cortisol and inflammatory markers often rise.

Lifestyle factors accelerate this process:

Chronic stress and poor sleep lower testosterone production.
Excess visceral fat increases conversion of testosterone to oestradiol.
Sedentary habits reduce muscle mass and metabolic activity.
Environmental toxins disrupt endocrine balance.

Studies published in the European Urology Journal and Endocrine Reviews have shown that low testosterone is associated with higher rates of obesity, cardiovascular disease, and type 2 diabetes.

By identifying these patterns early, we can correct them — improving not only hormonal balance but overall longevity.

[Explore Hormonal Health → /hormonal-health/]
[Learn About Metabolic Health → /metabolic-health-assessment/]

Recognising the Symptoms of Andropause

The signs of hormonal decline appear gradually and are often mistaken for “getting older” or “burnout.”

Common symptoms include:

Persistent fatigue and loss of drive

Decreased muscle mass, increased abdominal fat

Reduced libido or erectile difficulties

Sleep disruption or early morning waking

Irritability, anxiety, and low mood

Poor concentration and memory

Andropause is not inevitable — and it is reversible with the right medical care.
Identifying hormonal decline is the first step toward recovery.

[Visit Men’s Sexual Health → /men’s-sexual-health/]
[Learn About Urological Health → /urological-health/]

The Science Behind Male Hormonal Ageing

Hormonal decline is regulated by the hypothalamic–pituitary–gonadal (HPG) axis, which controls the production of testosterone in the testes.
With age and stress, this system becomes less responsive.

The hypothalamus releases less gonadotropin-releasing hormone (GnRH).
The pituitary gland produces less luteinising hormone (LH).
The testes respond less efficiently, reducing testosterone output.

At the same time, sex hormone-binding globulin (SHBG) rises, making less testosterone available for use.
Cortisol and oestradiol may increase, adding metabolic and mood-related symptoms.

This imbalance is known as functional hypogonadism — a correctable condition where hormone levels are low despite normal testicular function.

[View Hormone Testing → /hormone-testing/]
[Learn About Longevity Medicine → /longevity-medicine/]

Diagnosis: Precision Testing for Men’s Health

We use a combination of laboratory and clinical evaluation to confirm andropause and rule out other causes.

Your Men’s Health Assessment includes:

Blood analysis for total and free testosterone, SHBG, and estradiol
Thyroid, adrenal, and pituitary hormone evaluation
PSA, lipid profile, and cardiovascular risk assessment
Symptom scoring and clinical history review

Diagnosis focuses on correlation — how hormone levels align with symptoms, metabolism, and energy.
This approach ensures therapy is safe, evidence-based, and individually tailored.

[Book Diagnostic Assessment → /health-assessments/]
[Explore Hormone Testing → /hormone-testing/]

Testosterone Replacement Therapy (TRT)

When clinically indicated, Testosterone Replacement Therapy (TRT) is one of the most effective treatments for andropause.
By restoring physiological testosterone levels, TRT can:

Improve mood, energy, and motivation
Enhance libido and erectile function
Increase lean muscle mass and bone density
Reduce abdominal fat and insulin resistance

TRT is available in several forms, including topical gels, injections, or long-acting implants.
We monitor blood levels, haematocrit, prostate markers, and cardiovascular indicators to ensure safety and optimal outcomes.

Research from The Journal of Clinical Endocrinology & Metabolism confirms that medically supervised TRT can significantly improve quality of life and reduce metabolic risk.

[Learn About Testosterone Therapy → /testosterone-replacement-therapy/]
[Discuss Hormonal Health → /hormonal-health/]

Beyond Testosterone: Regenerative Support for Male Vitality

Hormonal restoration is only part of the solution.
We combine TRT with regenerative medicine and functional therapies to support mitochondrial health, reduce inflammation, and restore full vitality.

Our integrated protocols include:

NAD+ infusions to improve cellular energy
Peptide therapy to enhance recovery and sleep
Nutritional optimisation for hormone metabolism
Stress management and circadian rhythm correction

These interventions accelerate recovery, improving both physical and cognitive performance.

[Explore Regenerative Medicine → /regenerative-medicine/]
[Join Longevity Programs → /longevity-programs/]

The Link Between Andropause, Metabolic Syndrome, and Cardiovascular Health

Low testosterone and insulin resistance often occur together.
Andropause increases abdominal fat, raises triglycerides, and lowers HDL cholesterol — all markers of metabolic syndrome.
This combination raises cardiovascular risk and accelerates biological ageing.

By addressing hormonal decline through lifestyle, medical therapy, and regenerative care, we can reverse these patterns and restore balance.

[Assess Metabolic Health → /metabolic-health-assessment/]
[Check Cardiovascular Risk → /cardiovascular-screening/]

Sexual and Urological Health

Sexual performance and urinary function are closely tied to hormonal and vascular health.
Erectile dysfunction is often the first visible sign of vascular ageing or testosterone decline.

Our Men’s Sexual Health and Urological Health services, led by Dr Stefanos Kachrilas, investigate the full spectrum of male function — from hormone testing to vascular imaging and regenerative treatments.

[Explore Men’s Sexual Health → /men’s-sexual-health/]
[Visit Urological Health → /urological-health/]

A Longevity Medicine Approach for Men

Treating andropause is part of the wider Longevity Medicine philosophy — measuring, monitoring, and optimising every system of the body.
By integrating diagnostics, hormone therapy, nutrition, and regenerative protocols, we target the biological mechanisms of ageing.

Each plan includes continuous tracking of:

Hormone ratios (testosterone to estradiol, cortisol balance)
Metabolic markers (insulin sensitivity, lipid ratios)
Inflammatory and mitochondrial indices

Our goal is not only to restore testosterone but to build long-term vitality and healthspan.

[Learn About Longevity Medicine → /longevity-medicine/]
[Join Longevity Programs → /longevity-programs/]

Regain Control of Your Energy and Wellbeing

Andropause doesn’t define ageing — it’s a signal that your body needs balance.
With modern diagnostics and precise treatment, you can restore strength, energy, and mental clarity.

Start your transformation today.

[Book Men’s Health Assessment → /health-assessments/]
[Discuss Testosterone Therapy → /testosterone-replacement-therapy/]
[Meet Dr Stefanos Kachrilas → /about-dr-stefanos-kachrilas/]

Your questions are always welcome